Scale Up

From Laboratory to Semi-Industrial Scale

Unleashing Scientific Advancements

Making anything bigger requires more materials, time, and effort - HFC's team of experts can help take your laboratory concepts into economically-feasible semi-industrial scale products.

What is Scale Up?

Scale up involves expanding the production of a chemical compound, usually moving from small-scale laboratory production to larger semi-industrial-scale operations. For those new to scaling up a process from the lab, it is essential to recognize that the pilot plant scale-up is not a straightforward progression. This means that one cannot simply take a laboratory process, multiply the chemicals and equipment, and transplant them directly into a pilot plant. As you increase the scale of your chemical process, various system size-dependent properties will also vary.

In the fine chemicals and pharmaceutical industries, transitioning from lab to semi-industrial scale is a crucial step. The success of this phase influences the feasibility of the new product's development process according to client quality standards. Undertaking or refining a scale-up process may require the adoption of novel production or separation techniques. Outsourcing this development phase enables companies to access specialized facilities and expertise, enhancing their in-house development capabilities.

Understanding the Foundation

Before proceeding with scale-up, it's crucial to thoroughly understand the core principles driving the reaction. Familiarity with the reaction mechanism, kinetics, and thermodynamics helps predict how the reaction will perform on a larger scale. This knowledge provides direction throughout the process, helping us tackle potential obstacles.

The path to scaling up begins with careful, incremental progress. Conducting small-scale experiments provides an opportunity for optimization, helping us refine conditions and verify yields.

Risk Management

Approaching the challenges of scaling up chemical reactions is akin to painting a masterpiece on the canvas of scientific inquiry. As chemists and researchers, our motivation stems from a passion for expanding knowledge and making meaningful discoveries. Scaling up a reaction goes beyond merely increasing volume; it involves a delicate balance of comprehension, strategy, and creativity that leads to novel opportunities.

Scaling up introduces fresh obstacles and potential setbacks, but careful planning and proactive risk management techniques help protect the project from unforeseen complications.

Frequently Asked Questions

What information do I require before submitting a Request for Quotation (RFQ)?

Generally, you should give as much information as you can, because the more specific you are with your request, the more accurately we will be able to quote you and fulfill your needs. In general, we would require the following information:

  • Product Name
  • Molecular Formula (if known)
  • CAS No. (if known)
  • Quantity Required
  • Frequency of quantity required (eg. 10kg per month)
  • Purity
  • Application
  • Any references to publication or literature references (if available)
  • Reaction Scheme

What are the typical scales of HFC's Scale Up projects?

Our focus is on taking laboratory scale chemical compounds into semi-industrial scales, which typically means kilograms, and not tonnes.

We do not scale up compounds into industrial scales.

Our Scale Up projects are typically under contractual agreements with customers, wherein we agree the annual quantity with our customer and deliver a couple dozen kilograms of product on a monthly basis to them.

Will I be provided with a Non-Disclosure Agreement (NDA)?

All queries are dealt with strict confidentiality, however, if you would like to enter into a Non-Disclosure Agreement (NDA), please let our team know to be provided with one.

Scale Up Enquiry Form